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Monitoring of renal function in such patients should be considered. Upper GI ulcers/ulcer complications have occurred in patients treated with ETORICOXIB (ARCOXIA). Therefore, under conditions of compromised renal perfusion, administration of etoricoxib may cause a reduction in prostaglandin formation and, secondarily, in renal blood flow, and thereby impair renal function. In clinical trials, ARCOXIA has been shown to have a lower risk of serious side effects on the stomach (for example, bleeding stomach ulcers) than NSAIDs. Arcoxia tablets contain an active ingredient called etoricoxib.
Recommended dosage
Selective COX-2 inhibitors are not a substitute for aspirin for cardiovascular prophylaxis because of their lack of effect on platelets. Caution should be exercised in patients with a history of cardiac failure, left ventricular dysfunction, or hypertension and in patients with pre-existing oedema from any other reason. If you have ever had a stomach or duodenal ulcer, or if you have an inflammatory bowel disorder such as Crohn's disease or ulcerative colitis. You may need different amounts of your medicine, or you may need to take different medicines.
- Some selective COX-2 inhibitors have been associated with an increased risk of skin reactions in patients with a history of any drug allergy.
- The relative difference in gastrointestinal safety between selective COX-2 inhibitors + acetylsalicylic acid vs. If blood pressure rises significantly, alternative treatment should be considered.
- It does not matter if you take Arcoxia before or after food.
Side effects
Onset of efficacy was evaluated only in the 60mg studies and was demonstrated within the first 24 hours of initiating treatment. Upper GI ulcers/ulcer complications have occurred in patients treated with ETORICOXIB (ARCOXIA). However taking aspirin with ARCOXIA may reverse this benefit. NSAIDs + acetylsalicylic acid has not been adequately evaluated in long-term clinical trials. Caution should be used when initiating treatment with ETORICOXIB (ARCOXIA) in patients with considerable dehydration. Therefore, under conditions of compromised renal perfusion, administration of ETORICOXIB (ARCOXIA) may cause a reduction in prostaglandin formation and, secondarily, in renal blood flow, and thereby impair renal function.
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Because NSAIDs block the production of these prostaglandins, they are effective at relieving pain and inflammation. For the relief of gout attacks or other types of pain, Arcoxia is usually only needed for a few days. Arcoxia cannot replace aspirin for this purpose. Therefore, the daily doses stated above for each condition should not be exceeded.
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- Do not use Arcoxia for longer than your doctor says. It is important that you use the lowest dose that controls your pain and you should not take Arcoxia for longer than necessary.
- Try to take your doses at the same time of day each day as this will help you to remember to take them. In the absence of comparable data with etoricoxib, it may be assumed that patients at high risk of cardiovascular disease (including patients with diabetes, hyperlipidaemia, hypertension, or smokers) who are undergoing any major surgery may face an increased risk of developing a cardiovascular event.
- If you have trouble remembering to take your tablets, ask your pharmacist for some hints. Continue taking Arcoxia for as long as your doctor prescribes.
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You have a history of heart failure, or any other form of heart disease. Arcoxia relieves pain and inflammation with less risk of stomach ulcers compared to NSAIDS. This is because the risk of heart attacks and strokes might increase after prolonged treatment, especially with high doses. This includes any medicines you are taking which are available to buy without a prescription, as well as as herbal and complementary medicines.
Precautions
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It works in a similar way to traditional anti-inflammatory medicines, known as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), by blocking the production of substances that cause pain and inflammation. For information regarding a dose related response for etoricoxib see section 5.1. Some selective COX-2 inhibitors have been associated with an increased risk of skin reactions in patients with a history of any drug allergy. There are no clinical or pharmacokinetic data in patients with severe hepatic insufficiency. This is because the risk of heart attacks and strokes might increase after prolonged treatment, especially with high doses.
